MRI guided Focused ultrasound for the treatment of ischemic stroke

Period 15/7/2009-31/7/2013

CORDINATOR MEDSONIC LTD

This project is funded by the Research Promotion foundation of Cyprus. (www.research.org.cy) and the European regional development structural funds (project number ΑΝΑΒΑΘΜΙΣΗ/ΠΑΓΙΟ/0308/05

eu rpf roc

SUMMARY OF GRANT

The potential of MRI-guided focused ultrasound (MRgFUS) combined with the thrombolytic drug recombinant tissue plasminogen activator (rt-PA), to dissolve clots in the carotid of a New Zealand rabbit in vivo is evaluated. A spherically-focused transducers of 5 cm diameter; focusing at 10 cm and operating at 1 MHz was used. A pulsed ultrasound protocol was used that maintains a tissue temperature increase of less than 1ºC in the clot (called safe temperature). MRgFUS has the potentials to dissolve clots that are injected in the carotid of rabbits in vivo. It was found that the time needed for opening the carotid artery using ultrasound and rt-PA was decreased compared to just using rt-PA. The time needed for opening the artery decreases with increasing acoustic intensity. With an intensity of 20 W/cm2 (SATA) which is not causing artery heating the time needed to completely open the artery was 70 mins. The proposed protocol was monitored using Magnetic Resonance Angiography (MRA) every 1 min.

Transducer holder (stationary experiments)
transducerholder transducerholdertop
Positioning device
positioningdevice
In vitro model
invitromodel invitromodel2

Transducer coupling

transducercoupling  

Blocked artery (rabbit model)

blocked  

Effect of intensity on the blocked artery

intensity

CONCLUSIONS

Clear benefit from FUS in opening blocked arteries.

FUTURE WORK

For more info you can contact: cdamianou@cytanet.com.cy